I ran accorss a install of a word automation project that worked locally but would not run on our production server. Windows 2008 64bit.

In the end all that was needed was to add two folders for the desktop and it ran fine.

This solution is ...

・Windows 2008 Server x64

Please make this folder.

C:\Windows\SysWOW64\config\systemprofile\Desktop

・Windows 2008 Server x86

Please make this folder.

C:\Windows\System32\config\systemprofile\Desktop

http://stackoverflow.com/questions/863864/excel-2007-automation-on-top-of-a-windows-server-2008-x64